The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might lead to an increase in methadone plasma concentrations, which could bring about likely lethal respiratory despair. In addition, discontinuation of concomitantly applied cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may additionally cause a rise